IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

OBJECTIVE: High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including...

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Bibliografski detalji
Glavni autori: Niewold, Timothy B, Kelly, Jennifer A, Kariuki, Silvia N, Franek, Beverly S, Kumar, Akaash A, Kaufman, Kenneth M, Thomas, Kenaz, Walker, Daniel, Kamp, Stan, Frost, Jacqueline M, Wong, Andrew K, Merrill, Joan T, Alarcón-Riquelme, Marta E, Tikly, Mohammed, Ramsey-Goldman, Rosalind, Reveille, John D, Petri, Michelle A, Edberg, Jeffrey C, Kimberly, Robert P, Alarcón, Graciela S, Kamen, Diane L, Gilkeson, Gary S, Vyse, Timothy J, James, Judith A, Gaffney, Patrick M, Moser, Kathy L, Crow, Mary K, Harley, John B
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307526/
https://ncbi.nlm.nih.gov/pubmed/22088620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200463
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