IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

OBJECTIVE: High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including...

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Main Authors: Niewold, Timothy B, Kelly, Jennifer A, Kariuki, Silvia N, Franek, Beverly S, Kumar, Akaash A, Kaufman, Kenneth M, Thomas, Kenaz, Walker, Daniel, Kamp, Stan, Frost, Jacqueline M, Wong, Andrew K, Merrill, Joan T, Alarcón-Riquelme, Marta E, Tikly, Mohammed, Ramsey-Goldman, Rosalind, Reveille, John D, Petri, Michelle A, Edberg, Jeffrey C, Kimberly, Robert P, Alarcón, Graciela S, Kamen, Diane L, Gilkeson, Gary S, Vyse, Timothy J, James, Judith A, Gaffney, Patrick M, Moser, Kathy L, Crow, Mary K, Harley, John B
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307526/
https://ncbi.nlm.nih.gov/pubmed/22088620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200463
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