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Chromodomain Helicase DNA-binding Protein 4 (CHD4) Regulates Homologous Recombination DNA Repair, and Its Deficiency Sensitizes Cells to Poly(ADP-ribose) Polymerase (PARP) Inhibitor Treatment

To ensure genome stability, cells have evolved a robust defense mechanism to detect, signal, and repair damaged DNA that is generated by exogenous stressors such as ionizing radiation, endogenous stressors such as free radicals, or normal physiological processes such as DNA replication. Homologous r...

詳細記述

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書誌詳細
主要な著者: Pan, Mei-Ren, Hsieh, Hui-Ju, Dai, Hui, Hung, Wen-Chun, Li, Kaiyi, Peng, Guang, Lin, Shiaw-Yih
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307306/
https://ncbi.nlm.nih.gov/pubmed/22219182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.287037
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