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RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1
Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease caused by abnormal transcripts containing expanded CUG repeats. The CUG transcripts aggregate in the nucleus to form RNA foci and lead to nuclear depletion of Muscleblind-like 1 (MBNL1) and stabilized expression of CUGBP Elav like family 1 (...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306674/ https://ncbi.nlm.nih.gov/pubmed/22371589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117019109 |
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