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The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations

BACKGROUND: The role of Notch signaling in HPV-mediated transformation has been a long standing debate, as both tumor suppressive and oncogenic properties have been described. We examined whether the dual findings in literature may be explained by gene dosage effects and determined the relation with...

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Main Authors: Henken, Florianne E., De-Castro Arce, Johanna, Rösl, Frank, Bosch, Leontien, Meijer, Chris J. L. M., Snijders, Peter J. F., Steenbergen, Renske D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306567/
https://ncbi.nlm.nih.gov/pubmed/22271085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-011-0062-4
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