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Importance of electrostatic polarizability in calculating cysteine acidity constants and copper(I) binding energy of Bacillus subtilis CopZ

CopZ is a copper chaperone from Bacillus subtilis. It is an important part of Cu(I) trafficking. We have calculated pKa values for the CXXC motif of this protein which is responsible for the Cu(I) binding, and the Cu(I) binding constants. Polarizable and fixed-charges formalisms were employed, and s...

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Bibliografski detalji
Glavni autori: Click, Timothy H., Ponomarev, Sergei Y., Kaminski, George A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306534/
https://ncbi.nlm.nih.gov/pubmed/22370900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.22944
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