Mechanisms of CHD5 Inactivation in Neuroblastomas

PURPOSE: Neuroblastomas (NBs) have genomic, biological and clinical heterogeneity. High-risk NBs are characterized by several genomic changes, including MYCN amplification and 1p36 deletion. We identified the chromatin-remodeling gene CHD5 as a tumor suppressor gene that maps to 1p36.31. Low or abse...

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Bibliographic Details
Main Authors: Koyama, Hiroshi, Zhuang, Tiangang, Light, Jennifer E., Kolla, Venkatadri, Higashi, Mayumi, McGrady, Patrick W., London, Wendy B., Brodeur, Garrett M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306487/
https://ncbi.nlm.nih.gov/pubmed/22294723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2644
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