Prognostic and Predictive Significance of Plasma HGF and IL8 in a Phase III trial of Chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer

PURPOSE: HGF is a hypoxia-induced secreted protein that binds to cMET and regulates IL8 expression. We evaluated the role of circulating HGF and IL8 as prognostic and predictive factors for efficacy of tirapazamine (TPZ), a hypoxic cell cytotoxin. EXPERIMENTAL DESIGN: Patients with Stage III–IV head...

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Autori principali: Le, Quynh-Thu, Fisher, Richard, Oliner, Kelly S., Young, Richard J., Cao, Hongbin, Kong, Christina, Graves, Edward, Hicks, Rodney J, McArthur, Grant A., Peters, Lester, O’Sullivan, Brian, Giaccia, Amato, Rischin, Danny
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306471/
https://ncbi.nlm.nih.gov/pubmed/22383739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2094
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