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Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1(G93A) and SOD1(H46R), Exert Distinct Harmful Effects on Gross Phenotype in Mice
Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of fatal neurodegenerative diseases characterized by a selective loss of motor neurons in the brain and spinal cord. Creation of transgenic mice expressing mutant Cu/Zn superoxide dismutase (SOD1), as ALS models, has made an enormous impac...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306410/ https://ncbi.nlm.nih.gov/pubmed/22438926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033409 |
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