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Structures of Helicobacter pylori Shikimate Kinase Reveal a Selective Inhibitor-Induced-Fit Mechanism

Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids. This pathway is present in bacteria, fungi, and plants but absent in...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Hsu, Kai-Cheng, Lin, Shuang-Chih, Chen, Tzu-Jung, Yang, Jinn-Moon, Wang, Wen-Ching
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306394/
https://ncbi.nlm.nih.gov/pubmed/22438938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033481
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