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Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways

Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of “one–disease, one–target, one–drug”. The hit rates of these methods are often low because they cannot capture the features that play key roles in the biological functions of the targe...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Wen-Ching, Yang, Jinn-Moon
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701698/
https://ncbi.nlm.nih.gov/pubmed/23861662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003127
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