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Prediction of Promiscuous P-Glycoprotein Inhibition Using a Novel Machine Learning Scheme
BACKGROUND: P-glycoprotein (P-gp) is an ATP-dependent membrane transporter that plays a pivotal role in eliminating xenobiotics by active extrusion of xenobiotics from the cell. Multidrug resistance (MDR) is highly associated with the over-expression of P-gp by cells, resulting in increased efflux o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306300/ https://ncbi.nlm.nih.gov/pubmed/22439003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033829 |
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