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Prediction of Promiscuous P-Glycoprotein Inhibition Using a Novel Machine Learning Scheme

BACKGROUND: P-glycoprotein (P-gp) is an ATP-dependent membrane transporter that plays a pivotal role in eliminating xenobiotics by active extrusion of xenobiotics from the cell. Multidrug resistance (MDR) is highly associated with the over-expression of P-gp by cells, resulting in increased efflux o...

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Bibliografske podrobnosti
Main Authors: Leong, Max K., Chen, Hong-Bin, Shih, Yu-Hsuan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306300/
https://ncbi.nlm.nih.gov/pubmed/22439003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033829
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