Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules

BACKGROUND: Enzastaurin, an oral serine–threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS: We analysed the anti-tumour effects of...

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Главные авторы: Shimokawa, T, Seike, M, Soeno, C, Uesaka, H, Miyanaga, A, Mizutani, H, Kitamura, K, Minegishi, Y, Noro, R, Okano, T, Yoshimura, A, Gemma, A
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305973/
https://ncbi.nlm.nih.gov/pubmed/22333600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.7
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