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Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs

We investigated the antitumour effect and ability to overcome the resistance to anti-EGFR drugs of enzastaurin, an inhibitor of VEGFR-dependent PKCβ signalling. Enzastaurin was evaluated alone and in combination with the EGFR inhibitor gefitinib, on growth and signalling protein expression in human...

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Detalhes bibliográficos
Main Authors: Gelardi, T, Caputo, R, Damiano, V, Daniele, G, Pepe, S, Ciardiello, F, Lahn, M, Bianco, R, Tortora, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527788/
https://ncbi.nlm.nih.gov/pubmed/18665191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604493
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