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Keap1-Nrf2 Activation in the Presence and Absence of DJ-1

The molecular mechanisms leading to neurodegeneration in Parkinson’s disease remain elusive. Deletion and mutations of DJ-1 (PARK7) have been reported to cause autosomal recessive familial Parkinson’s disease. Wildtype DJ-1 scavenges H(2)O(2) by cysteine oxidation in response to oxidative stress, an...

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Autori principali: Gan, Li, Johnson, Delinda A., Johnson, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305788/
https://ncbi.nlm.nih.gov/pubmed/20377612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07138.x
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