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Mapping the Hsp90 Genetic Interaction Network in Candida albicans Reveals Environmental Contingency and Rewired Circuitry

The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90 interacts with ∼10% of the proteome in the model yeast Saccharomyces cerevisiae,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Diezmann, Stephanie, Michaut, Magali, Shapiro, Rebecca S., Bader, Gary D., Cowen, Leah E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305360/
https://ncbi.nlm.nih.gov/pubmed/22438817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002562
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