Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and displa...

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Autores principales: Liu, Ju-Ling, Desjardins, David, Branicky, Robyn, Agellon, Luis B., Hekimi, Siegfried
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305355/
https://ncbi.nlm.nih.gov/pubmed/22438816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002553
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