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Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach
A prodrug strategy was applied to guanidino-containing analogs to increase oral absorption via hPEPT1 and hVACVase. L-Valine, L-isoleucine and L-phenylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized and evaluated for transport and activation. In HeLa/hPEPT1 cells, Val-3...
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| Hoofdauteurs: | , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304101/ https://ncbi.nlm.nih.gov/pubmed/19957998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9011559 |
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