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Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach

A prodrug strategy was applied to guanidino-containing analogs to increase oral absorption via hPEPT1 and hVACVase. L-Valine, L-isoleucine and L-phenylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized and evaluated for transport and activation. In HeLa/hPEPT1 cells, Val-3...

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Bibliografiske detaljer
Main Authors: Sun, Jing, Dahan, Arik, Amidon, Gordon L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304101/
https://ncbi.nlm.nih.gov/pubmed/19957998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9011559
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