Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift

This paper describes a new program SnpSift for filtering differential DNA sequence variants between two or more experimental genomes after genotoxic chemical exposure. Here, we illustrate how SnpSift can be used to identify candidate phenotype-relevant variants including single nucleotide polymorphi...

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Bibliografiske detaljer
Main Authors: Cingolani, Pablo, Patel, Viral M., Coon, Melissa, Nguyen, Tung, Land, Susan J., Ruden, Douglas M., Lu, Xiangyi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Research Foundation 2012
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304048/
https://ncbi.nlm.nih.gov/pubmed/22435069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00035
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