AMMONIA INCREASES PARACELLULAR PERMEABILITY OF RAT BRAIN ENDOTHELIAL CELLS BY A MECHANISM ENCOMPASSING OXIDATIVE/NITROSATIVE STRESS AND ACTIVATION OF MATRIX METALLOPROTEINASES

Ammonia is responsible for cerebral edema (CE) associated with acute liver failure (ALF), but the role of the vasogenic mechanism has been a matter of dispute. Here, we tested the hypothesis that ammonia induces changes in blood-brain barrier (BBB) permeability by a mechanism coupled to oxidative/ n...

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Bibliographic Details
Main Authors: Skowrońska, Marta, Zielińska, Magdalena, Wójcik-Stanaszek, Luiza, Ruszkiewicz, Joanna, Milatovic, Dejan, Aschner, Michael, Albrecht, Jan
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303972/
https://ncbi.nlm.nih.gov/pubmed/22260250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07669.x
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