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The Terminal Substituents of 7α, 6-hexanyl Derivatives of Estradiol Determine their Selective Estrogen Receptor Modulator versus Agonist Activities
Pure antiestrogens were clinically developed as alternative therapies for estrogen receptor (ER) positive breast cancers. Unlike the selective estrogen receptor modulators (SERMs), these antiestrogens are devoid of tissue-specific ER agonist activity. Many of these compounds are steroidal in nature,...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3303951/ https://ncbi.nlm.nih.gov/pubmed/22326682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2012.01.011 |
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