C-Terminal Extension of the Yeast Mitochondrial DNA Polymerase Determines the Balance between Synthesis and Degradation

Saccharomyces cerevisiae mitochondrial DNA polymerase (Mip1) contains a C-terminal extension (CTE) of 279 amino acid residues. The CTE is required for mitochondrial DNA maintenance in yeast but is absent in higher eukaryotes. Here we use recombinant Mip1 C-terminal deletion mutants to investigate fu...

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Main Authors: Viikov, Katrin, Jasnovidova, Olga, Tamm, Tiina, Sedman, Juhan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303844/
https://ncbi.nlm.nih.gov/pubmed/22432028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033482
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