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On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions

BACKGROUND: Non-synonymous coding SNPs (nsSNPs) that are associated to disease can also be related with alterations in protein stability. Computational methods are available to predict the effect of single amino acid substitutions (SASs) on protein stability based on a single folded structure. Howev...

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Hlavní autoři: Juritz, Ezequiel, Fornasari, Maria Silvina, Martelli, Pier Luigi, Fariselli, Piero, Casadio, Rita, Parisi, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303731/
https://ncbi.nlm.nih.gov/pubmed/22759653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-S4-S5
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