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On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions
BACKGROUND: Non-synonymous coding SNPs (nsSNPs) that are associated to disease can also be related with alterations in protein stability. Computational methods are available to predict the effect of single amino acid substitutions (SASs) on protein stability based on a single folded structure. Howev...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3303731/ https://ncbi.nlm.nih.gov/pubmed/22759653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-S4-S5 |
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