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On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions

BACKGROUND: Non-synonymous coding SNPs (nsSNPs) that are associated to disease can also be related with alterations in protein stability. Computational methods are available to predict the effect of single amino acid substitutions (SASs) on protein stability based on a single folded structure. Howev...

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主要な著者: Juritz, Ezequiel, Fornasari, Maria Silvina, Martelli, Pier Luigi, Fariselli, Piero, Casadio, Rita, Parisi, Gustavo
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303731/
https://ncbi.nlm.nih.gov/pubmed/22759653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-S4-S5
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