Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine.
Dithymidine-3'-S-phosphorothioate (d(TspT)) has been prepared from a 5'-O-monomethoxytritylthymidine-3'-S-phosphorothioamidite (7) by activation with 5-(p-nitrophenyl)tetrazole in the presence of 3'-O-acetylthymidine. The resulting dinucleoside phosphorothioite is readily oxidised to the correspondi...
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| Veröffentlicht in: | Nucleic Acids Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1990
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2315041/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.4.829 |
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