Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine.

Dithymidine-3'-S-phosphorothioate (d(TspT)) has been prepared from a 5'-O-monomethoxytritylthymidine-3'-S-phosphorothioamidite (7) by activation with 5-(p-nitrophenyl)tetrazole in the presence of 3'-O-acetylthymidine. The resulting dinucleoside phosphorothioite is readily oxidise...

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Bibliografiske detaljer
Main Authors: Cosstick, R, Vyle, J S
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC330334/
https://ncbi.nlm.nih.gov/pubmed/2315041
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