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Strong physical constraints on sequence-specific target location by proteins on DNA molecules

Sequence-specific binding to DNA in the presence of competing non-sequence-specific ligands is a problem faced by proteins in all organisms. It is akin to the problem of parking a truck at a loading bay by the side of a road in the presence of cars parked at random along the road. Cars even partiall...

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Autors principals: Flyvbjerg, Henrik, Keatch, Steven A., Dryden, David T.F.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303175/
https://ncbi.nlm.nih.gov/pubmed/16698961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl271
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