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In vivo Notch Reactivation in Differentiating Cochlear Hair Cells Induces Sox2 and Prox1 Expression but Does Not Disrupt Hair Cell Maturation

Notch signaling is active in mouse cochlear prosensory progenitors but declines in differentiating sensory hair cells (HCs). Overactivation of the Notch1 intracellular domain (NICD) in progenitors blocks HC fate commitment and/or differentiation. However, it is not known whether reactivation of NICD...

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Detalhes bibliográficos
Main Authors: Liu, Zhiyong, Owen, Thomas, Fang, Jie, Srinivasan, R. Sathish, Zuo, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302943/
https://ncbi.nlm.nih.gov/pubmed/22354878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.23754
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