Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

BACKGROUND: Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, the objective response rates of rapamycin achieved with single-agent therapy were modest, supporting that rapamycin resistance is a frequently observed characteris...

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Detalhes bibliográficos
Main Authors: Li, Quan-Lin, Gu, Fang-Ming, Wang, Zheng, Jiang, Jia-Hao, Yao, Li-Qing, Tan, Chang-Jun, Huang, Xiao-Yong, Ke, Ai-Wu, Dai, Zhi, Fan, Jia, Zhou, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302853/
https://ncbi.nlm.nih.gov/pubmed/22428038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033379
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