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Spinal heat shock protein 27 participates in PDGFRβ‐mediated morphine tolerance through PI3K/Akt and p38 MAPK signalling pathways

BACKGROUND AND PURPOSE: The development of antinociceptive morphine tolerance is a clinically intractable problem. Earlier work has demonstrated the pivotal roles of PDGF and its receptor PDGFRβ in morphine tolerance. Here, we have investigated the role of spinal heat shock protein 27 (HSP27) in mor...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Li, Zheng, Peng, Xiaoling, Jia, Xiaoqian, Su, Peng, Liu, Daiqiang, Tu, Ye, Xu, Qiaoqiao, Gao, Feng
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589020/
https://ncbi.nlm.nih.gov/pubmed/32559815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15169
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