Prognostic Value of Three Different Methods of MGMT Promoter Methylation Analysis in a Prospective Trial on Newly Diagnosed Glioblastoma

Hypermethylation in the promoter region of the MGMT gene encoding the DNA repair protein O(6)-methylguanine-DNA methyltransferase is among the most important prognostic factors for patients with glioblastoma and predicts response to treatment with alkylating agents like temozolomide. Hence, the MGMT...

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Bibliografiske detaljer
Main Authors: Christians, Arne, Hartmann, Christian, Benner, Axel, Meyer, Jochen, von Deimling, Andreas, Weller, Michael, Wick, Wolfgang, Weiler, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302822/
https://ncbi.nlm.nih.gov/pubmed/22428052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033449
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