Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

Human noroviruses are genetically and antigenically highly divergent. Monoclonal antibodies raised in mice against one kind of norovirus virus-like particle (VLP), however, were found to have broad recognition. In this study, we present the crystal structure of the antigen-binding fragment (Fab) for...

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Hlavní autoři: Hansman, Grant S., Taylor, David W., McLellan, Jason S., Smith, Thomas J., Georgiev, Ivelin, Tame, Jeremy R. H., Park, Sam-Yong, Yamazaki, Makoto, Gondaira, Fumio, Miki, Motohiro, Katayama, Kazuhiko, Murata, Kazuyoshi, Kwong, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302548/
https://ncbi.nlm.nih.gov/pubmed/22278249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06868-11
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