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Induction of Immunological Tolerance to Adenoviral Vectors by Using a Novel Dendritic Cell-Based Strategy

The success of helper-dependent adenoviral (HD-Ad) vector-mediated lung gene therapy is hampered by the host immune response, which limits pulmonary transgene expression following multiple rounds of vector readminstration. Here, we show that HD-Ad-mediated pulmonary gene expression is sustained even...

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Hlavní autoři: Kushwah, Rahul, Oliver, Jordan R., Duan, Rongqi, Zhang, Li, Keshavjee, Shaf, Hu, Jim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302513/
https://ncbi.nlm.nih.gov/pubmed/22258241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06172-11
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