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Distinct Transformation Tropism Exhibited by Human T Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Is the Result of Postinfection T Cell Clonal Expansion

Human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 are related but pathogenically distinct viruses. HTLV-1 mainly causes adult T cell leukemia, while HTLV-2 is not associated with leukemia. In vitro, HTLV-1 and HTLV-2 predominantly transform CD4(+) and CD8(+) T cells, respectively: the genetic de...

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Библиографические подробности
Главные авторы: Kannian, Priya, Yin, Han, Doueiri, Rami, Lairmore, Michael D., Fernandez, Soledad, Green, Patrick L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302488/
https://ncbi.nlm.nih.gov/pubmed/22278223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06900-11
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