High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection

Broad and potent neutralizing antibody (BNAb) responses are rare in people infected by human immunodeficiency virus type 1 (HIV-1). Clearly defining the nature of BNAb epitopes on HIV-1 envelope glycoproteins (Envs) targeted in vivo is critical for future directions of anti-HIV-1 vaccine development...

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Bibliographic Details
Main Authors: Lavine, Christy L., Lao, Socheata, Montefiori, David C., Haynes, Barton F., Sodroski, Joseph G., Yang, Xinzhen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302386/
https://ncbi.nlm.nih.gov/pubmed/22156525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06201-11
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