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Mutating Conserved Cysteines in the Alphavirus E2 Glycoprotein Causes Virus-Specific Assembly Defects

There are 80 trimeric, glycoprotein spikes that cover the surface of an alphavirus particle. The spikes, which are composed of three E2 and E1 glycoprotein heterodimers, are responsible for receptor binding and mediating fusion between the viral and host-cell membranes during entry. In addition, the...

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Main Authors: Snyder, Anthony J., Sokoloski, Kevin J., Mukhopadhyay, Suchetana
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302346/
https://ncbi.nlm.nih.gov/pubmed/22238319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06615-11
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