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An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF-κB Activation
The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein actively shuttles between the nucleus, where it interacts with transcriptional and splicing regulatory proteins, and the cytoplasm, where it activates NF-κB. Posttranslational modifications of Tax such as ubiquitination regulate its sub...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302326/ https://ncbi.nlm.nih.gov/pubmed/22258247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06456-11 |
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