Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

Orthopoxviruses include the prototypical vaccinia virus, the emerging infectious agent monkeypox virus, and the potential biothreat variola virus (the causative agent of smallpox). There is currently no FDA-approved drug for humans infected with orthopoxviruses. We screened a diversity-oriented synt...

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Detalhes bibliográficos
Main Authors: Dower, Ken, Filone, Claire Marie, Hodges, Erin N., Bjornson, Zach B., Rubins, Kathleen H., Brown, Lauren E., Schaus, Scott, Hensley, Lisa E., Connor, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302283/
https://ncbi.nlm.nih.gov/pubmed/22205744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05416-11
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