Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

Orthopoxviruses include the prototypical vaccinia virus, the emerging infectious agent monkeypox virus, and the potential biothreat variola virus (the causative agent of smallpox). There is currently no FDA-approved drug for humans infected with orthopoxviruses. We screened a diversity-oriented synt...

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Main Authors: Dower, Ken, Filone, Claire Marie, Hodges, Erin N., Bjornson, Zach B., Rubins, Kathleen H., Brown, Lauren E., Schaus, Scott, Hensley, Lisa E., Connor, John H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302283/
https://ncbi.nlm.nih.gov/pubmed/22205744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05416-11
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