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Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

Orthopoxviruses include the prototypical vaccinia virus, the emerging infectious agent monkeypox virus, and the potential biothreat variola virus (the causative agent of smallpox). There is currently no FDA-approved drug for humans infected with orthopoxviruses. We screened a diversity-oriented synt...

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Autori principali: Dower, Ken, Filone, Claire Marie, Hodges, Erin N., Bjornson, Zach B., Rubins, Kathleen H., Brown, Lauren E., Schaus, Scott, Hensley, Lisa E., Connor, John H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302283/
https://ncbi.nlm.nih.gov/pubmed/22205744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05416-11
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