Coordinate Deletion of N-Glycans from the Heptad Repeats of the Fusion F Protein of Newcastle Disease Virus Yields a Hyperfusogenic Virus with Increased Replication, Virulence, and Immunogenicity

The role of N-linked glycosylation of the Newcastle disease virus (NDV) fusion (F) protein in viral replication and pathogenesis was examined by eliminating potential acceptor sites using a reverse genetics system for the moderately pathogenic strain Beaudette C (BC). The NDV-BC F protein contains s...

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Bibliographic Details
Main Authors: Samal, Sweety, Khattar, Sunil K., Kumar, Sachin, Collins, Peter L., Samal, Siba K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302274/
https://ncbi.nlm.nih.gov/pubmed/22205748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06380-11
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