Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

Antibody 14G7 is protective against lethal Ebola virus challenge and recognizes a distinct linear epitope in the prominent mucin-like domain of the Ebola virus glycoprotein GP. The structure of 14G7 in complex with its linear peptide epitope has now been determined to 2.8 Å. The structure shows that...

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Autores principales: Olal, Daniel, Kuehne, Ana I., Bale, Shridhar, Halfmann, Peter, Hashiguchi, Takao, Fusco, Marnie L., Lee, Jeffrey E., King, Liam B., Kawaoka, Yoshihiro, Dye, John M., Saphire, Erica Ollmann
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302272/
https://ncbi.nlm.nih.gov/pubmed/22171276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05549-11
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