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Noncatalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial Double-Stranded RNA Virus ϕ6 from De Novo Initiation to Elongation

RNA-dependent RNA polymerases (RdRps) are key to the replication of RNA viruses. A common divalent cation binding site, distinct from the positions of catalytic ions, has been identified in many viral RdRps. We have applied biochemical, biophysical, and structural approaches to show how the RdRp fro...

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Detalhes bibliográficos
Main Authors: Wright, Sam, Poranen, Minna M., Bamford, Dennis H., Stuart, David I., Grimes, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302264/
https://ncbi.nlm.nih.gov/pubmed/22205747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05168-11
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