Structural explanation for the role of Mn(2+) in the activity of ϕ6 RNA-dependent RNA polymerase

The biological role of manganese (Mn(2+)) has been a long-standing puzzle, since at low concentrations it activates several polymerases whilst at higher concentrations it inhibits. Viral RNA polymerases possess a common architecture, reminiscent of a closed right hand. The RNA-dependent RNA polymera...

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Detalhes bibliográficos
Main Authors: Poranen, Minna M., Salgado, Paula S., Koivunen, Minni R. L., Wright, Sam, Bamford, Dennis H., Stuart, David I., Grimes, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582606/
https://ncbi.nlm.nih.gov/pubmed/18940872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn632
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