Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes

Polycomb-group (PcG) proteins form the multiprotein polycomb repressive complexes (PRC) 1 and 2, and function as transcriptional repressors through histone modifications. They maintain the proliferative capacity of hematopoietic stem and progenitor cells by repressing the transcription of tumor supp...

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Hlavní autoři: Oguro, Hideyuki, Yuan, Jin, Tanaka, Satomi, Miyagi, Satoru, Mochizuki-Kashio, Makiko, Ichikawa, Hitoshi, Yamazaki, Satoshi, Koseki, Haruhiko, Nakauchi, Hiromitsu, Iwama, Atsushi
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302226/
https://ncbi.nlm.nih.gov/pubmed/22351929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111709
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