Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats

The sarco/endoplasmic reticulum (SR) Ca(2+)-ATPase SERCA2a has a key role in controlling cardiac contraction and relaxation. In hypothyroidism, decreased expression of the thyroid hormone (TH)-responsive SERCA2 gene contributes to slowed SR Ca(2+) reuptake and relaxation. We investigated whether car...

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Bibliographic Details
Main Authors: Vetter, Roland, Rehfeld, Uwe, Reissfelder, Christoph, Fechner, Henry, Seppet, Enn, Kreutz, Reinhold
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
Subjects:
Cardiovascular Neurohormonal Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302195/
https://ncbi.nlm.nih.gov/pubmed/21217071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00490.2010
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