MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis

Gefitinib, a small molecule inhibitor of the epidermal growth factor receptor tyrosine kinase, has been shown to induce autophagy as well as apoptosis in tumor cells. Yet, how to exploit autophagy and apoptosis to improve therapeutic efficacy of this drug against cancer remains to be explored. We re...

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Bibliographic Details
Main Authors: Cheng, Yan, Zhang, Yi, Zhang, Li, Ren, Xingcong, Huber-Keener, Kathryn J, Liu, Xiaoyuan, Zhou, Lei, Liao, Jason, Keihack, Heike, Yan, Li, Rubin, Eric, Yang, Jin-Ming
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302182/
https://ncbi.nlm.nih.gov/pubmed/22057914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0606
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