Presence of ApoE ε4 Allele Associated with Thinner Frontal Cortex in Middle Age

The presence of an ApoE ε4 allele (ε4+) increases the risk of developing Alzheimer’s disease (AD). Previous studies support an adverse relationship between ε4+ status and brain structure and function in mild cognitive impairment and AD; in contrast, the presence of an ε2 allele may be protective. Wh...

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Detalhes bibliográficos
Main Authors: Fennema-Notestine, Christine, Panizzon, Matthew S., Thompson, Wesley R., Chen, Chi-Hua, Eyler, Lisa T., Fischl, Bruce, Franz, Carol E., Grant, Michael D., Jak, Amy J., Jernigan, Terry L., Lyons, Michael J., Neale, Michael C., Seidman, Larry J., Tsuang, Ming T., Xian, Hong, Dale, Anders M., Kremen, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302177/
https://ncbi.nlm.nih.gov/pubmed/21971450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-0002
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