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Efficient generation of B lymphocytes by recognition of self-antigens
Antibody diversity is generated by a random gene recombination process with the inherent risk of the production of autoreactive specificities. The current view suggests that B cells expressing such specificities are negatively selected at an early developmental stage. Using the knock-in model system...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302163/ https://ncbi.nlm.nih.gov/pubmed/21604259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041344 |
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