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FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
Somatic rearrangement of immunoglobulin (Ig) genes is a key step during B cell development. Using pro–B cells lacking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinositide-3-kinase (PI3K) signaling, we show that PI3K signaling inhibits Ig gene rearrangeme...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280865/ https://ncbi.nlm.nih.gov/pubmed/22291095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110216 |
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