Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

A new variant of antithrombin (Rouen-VI, 187 Asn-->Asp) with increased heparin affinity was shown to have normal inhibitory activity which decreased slowly at 4 degrees C and rapidly at 41 degrees C. On electrophoresis the freshly isolated variant had an anodal shift relative to native antithrombin...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Bruce, D, Perry, D J, Borg, J Y, Carrell, R W, Wardell, M R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7989582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117589
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